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Ann-Sophie was born July 23, 1987 in Roeselare, a city in West Flanders, Belgium. She spent her youth in Izegem. After high school, she got her Masters Degree in Physical Education and Kinesiology at the University of Leuven. During her studies, Ann-Sophie focused on athletics and cycling.​

After a few years of experience in women's cycling, she started in 2012 on a professional level within the Lotto-Belisol Ladies team. She continued to be part of this team in 2013. During these years Ann-Sophie started to focus on time trial. It payed off fast: in 2012 she won the bronze medal at the Belgian Championship.​

In 2014 Ann-Sophie chose the Autoglas Wetteren Cyclingteam to continue her career. It was the beginning of her great breakthrough. In May 2014, at Hooglede-Gits, she became Belgian National Champion Time Trial. Thanks to this result, she represented Belgium on her first World Championship in Ponferrada. She ended up on a fifth place, only 45 seconds behind the winner.​

In 2015 Ann-Sophie signed a contract with the Topsport Vlaanderen-Pro-Duo team. She ended up 7th on the European Games and prolonged her Belgian title. In that same year she became 9th at the World Championship Time Trial.

​In 2016 Ann-Sophie won the Ljubljana-Domzale-Ljubljana TT and did win the Belgian National Champion TT again. In August she participated for the first time in the Olympics at Rio de Janeiro. She came 6th at the European Championship TT and ended up in 8th place at the World Championship TT. In October she won the famous Chrono des Nations at Les Herbiers in France.

​In 2017 Ann-Sophie joined the British Drops Cycling Team. She wins a stage and the mountain jersey in the Tour of Valencia, wins a second time the Ljubljana ITT and wins for the fourth time in a row the Belgian ITT Championship, a record! In July she wins the ITT at the Krasna Lipa (CZ) stage race and wins the silver medal at the European ITT Championships in Herning, Denmark. At the World Championships she suffers from a hip injury. She ends the season with a second place at the Chrono des Nations.

In 2018 Ann-Sophie joined Cervélo Bigla Pro Cycling Team and won the Belgian ITT Championship a 5th time, a national record!

In 2019 & 2020 Ann-Sophie was a rider for the Dutch Parkhotel Valkenburg Cycling Team. In september Ann-Sophie was diagnosed with a constricted pelvic artery, an injury that started to have a negative impact on performance from 2017. This was remedied by surgery. The 2020 season was also not without obstacles, when Ann-Sophie was able to resume the competition after the rehabilitation period, the Corona virus threw a spanner in the works worldwide and therefore also in the competition calendar. Despite this uncertain period, Ann-Sophie managed to win the national test time trial 'Memorial Igor Decraene' in September. 

In 2022 Ann-Sophie rode for the Belgian UCI team Multum Accountants Ladies Cycling Team. She won 4 races and the final classification of best Belgian rider in the Baloise Ladies Tour.

​Ann-Sophie lives in Hulste, a small city in West Flanders, Belgium. Her boyfriend is Casper van der Meer, a former Dutch professional cyclist. He runs his own cyclestore: Fietsen Casper.

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